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July 31, 2025NutrientsOpen Access

The Impact of Vitamin D Supplementation on Fasting Plasma Glucose, Insulin Sensitivity, and Inflammation in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

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Authors

EPEnny ProbosariHSHertanto Wahyu SubagioHHeri-Nugroho

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Overview

Systematic review reveals vitamin D supplementation improves insulin sensitivity and inflammation in type 2 diabetes, indicating its potential role in management.

Key Points

  • Vitamin D supplementation shows modest effects on fasting plasma glucose and insulin levels in type 2 diabetes.
  • Meta-analysis of nine studies reveals significant changes in biomarkers like HOMA-IR and hs-CRP after supplementation.
  • Clinical trials indicate a potential reduction in HbA1c by 0.30% and improved insulin sensitivity after 12 weeks.
  • Findings suggest vitamin D could help in managing diabetes, but the effects may diminish over time.

Cite This Study

Probosari et al. (2025) studied this question.

synapsesocial.com/papers/689a094be6551bb0af8cf3c9https://doi.org/10.3390/nu17152489
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effectiveness of Vitamin D Supplementation on Biochemical, Clinical, and Inflammatory Parameters in Patients with Different Types of Diabetes: A Systematic Review and Meta-Analysis2025 · 8 citations
  2. 2Vitamin D and type 2 diabetes mellitus: mechanisms, clinical evidence, and future perspectives2025
  3. 3The Role of Vitamin D Supplementation in Type 1, Type 2, and Gestational Diabetes: A Comprehensive Updated Narrative Review2025 · 6 citations
  4. 4Comparison of 25-hydroxy vitamin D with FBG and 2 hours postprandial glucose between type 2 diabetic and healthy normoglycemic individuals2025
  5. 5Impact Of Vitamin D Supplementation On Hba1c Level In Type 2 Diabetes Mellitus Patients Having Asymptomatic Vitamin D Deficiency In Northern Region Of Khyber Pakhtunkhwa, Pakistan A Prospective interventional Multi Center study.2025