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July 30, 2025International Journal of Molecular SciencesOpen Access

Molecular Mechanisms of Microvascular Obstruction and Dysfunction in Percutaneous Coronary Interventions: From Pathophysiology to Therapeutics—A Comprehensive Review

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Authors

ANAndré M NicolauPSPedro G. SilvaHMHector A. Mejia

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Overview

Comprehensive review reveals challenges of coronary microvascular obstruction after PCI in myocardial infarction patients, highlighting critical treatment gaps.

Key Points

  • Coronary microvascular obstruction frequently occurs after percutaneous coronary intervention, impacting clinical outcomes.
  • Key mechanisms of CMVO include ischemia, thrombotic embolization, and endothelial dysfunction, complicating recovery.
  • Gold standard for identifying CMVO is cardiac magnetic resonance imaging, with index of microvascular resistance as an alternative.
  • Current treatments like antiplatelet drugs and anticoagulants have not definitively reversed established CMVO, emphasizing the need for new strategies.

Cite This Study

Nicolau et al. (2025) studied this question.

synapsesocial.com/papers/689a0945e6551bb0af8cee63https://doi.org/10.3390/ijms26146835
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Coronary Microvascular Dysfunction: Pathophysiology, Clinical Phenotypes, and Mechanism-Guided Diagnostic Strategies2026
  2. 2Advancements in the Invasive Evaluation of Coronary Microvasculature in Acute Myocardial Infarction2025
  3. 3Bridging the Gap: A Comprehensive Toolkit for Assessment of Coronary Microcirculation in Clinical Practice2025 · 4 citations
  4. 4Impaired Coronary Microcirculation and Myocardial Systolic Function: A Narrative Review on Non-Invasive Assessment in Cardiovascular Diseases2025 · 3 citations
  5. 5Transcoronary Sinus Therapy for Coronary Microvascular Dysfunction2025