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July 28, 2025Open Access

Analyzing and Visualizing Distance Measures for Clonal Trees

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Authors

TTThea TrawQNQuoc V. NguyenLOLayla Oesper

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Overview

This work analyzes distance measures and introduces a visualization tool to compare clonal trees, highlighting key differences in their structure.

Key Points

  • Clonal trees represent tumor evolution through genomic mutations and ancestral relationships among cell clones.
  • This work defines four classes of differences in clonal trees and uses three distance measures to analyze them.
  • A new visualization tool, VECTr, enhances pairwise comparison of clonal trees, revealing key structural contributions to distance.
  • The findings support better understanding of tumor evolution, aiding in the interpretation of cancer genomic data.

Cite This Study

Traw et al. (2025) studied this question.

synapsesocial.com/papers/689a093fe6551bb0af8ceb65https://doi.org/10.1101/2025.07.18.665562
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