July 28, 2025VirusesOpen Access

Hemophagocytic Lymphohistiocytosis Triggered by Dengue: A Narrative Review and Individual Patient Data Meta-Analysis

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Discussion

Meta-analysis reveals significant mortality in dengue-associated hemophagocytic lymphohistiocytosis, indicating organ failure as a key risk factor.

Dengue-associated hemophagocytic lymphohistiocytosis affects predominantly young individuals, leading to high mortality rates.
Out of 133 analyzed patients, 19.3% died, with hepatic dysfunction significantly impacting prognosis.
Key symptoms included fever in 96.9% and organ dysfunction, necessitating early recognition for effective treatment.
Corticosteroids offered promising outcomes, emphasizing the need for prompt immunomodulatory intervention.

Sourris et al. (2025) studied this question.

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Meta-analysis reveals significant mortality in dengue-associated hemophagocytic lymphohistiocytosis, indicating organ failure as a key risk factor.