July 27, 2025

Interplay of BRAF and TERT promoter mutations and Ki67 proliferation index in papillary thyroid carcinoma in Central Asians

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Discussion

Retrospective analysis associates BRAF and TERT mutations with higher Ki67 in Kazakh PTC cases, suggesting aggressive cancer features.

BRAF V600E mutations were present in 68.3% of Kazakh patients with papillary thyroid carcinoma (PTC).
Co-occurring TERT promoter mutations correlated with advanced age and larger tumor size in PTC.
Higher Ki67 proliferation index was found in patients with concurrent BRAF and TERT mutations, indicating more aggressive cancer.
Mutations in PTC are critical in predicting cancer behavior and may assist in making treatment decisions for patients.

Targynova et al. (2025) studied this question.

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