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July 27, 2025Open Access

Methylation variability and LINE-1 activation in multiple myeloma

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Authors

QWQianhui WanALAmy LeungMBManish Bhandari

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Overview

Epigenome analysis demonstrates variable DNA methylation and LINE-1 activity in multiple myeloma, suggesting implications for tumor progression.

Key Points

  • Methylation loss in multiple myeloma is associated with diverse gene expression profiles among patients.
  • Activation of LINE-1 transposons correlates with reduced differentiation and higher proliferation in myeloma samples.
  • Abnormal levels of KRAB-zinc finger proteins are noted in samples with heightened LINE-1 activity, impacting epigenetic regulation.
  • Heterogeneous epigenetic changes provide potential clinical markers for disease progression in multiple myeloma.

Cite This Study

Wan et al. (2025) studied this question.

synapsesocial.com/papers/689a0939e6551bb0af8ce6fbhttps://doi.org/10.1101/2025.07.22.666173
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