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July 27, 2025Open Access

Protein risk scores enable precise prediction of cardiovascular events in chronic kidney disease patients

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Authors

YKYang‐Gyun KimYNYonghyun NamTWTrish Westbrook

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Overview

A protein risk score model predicts cardiovascular events in chronic kidney disease, suggesting biomarkers may enhance risk assessment.

Key Points

  • Protein risk scores effectively predict cardiovascular events in chronic kidney disease patients.
  • The study analyzed 2,920 plasma proteins, identifying 38 significant proteins linked to cardiovascular events.
  • The ProRS outperformed traditional clinical risk models, showing a 44.4% incidence in the highest risk group.
  • Mendelian randomization revealed key proteins affected by chronic kidney disease that correlate with cardiovascular disease.

Cite This Study

Kim et al. (2025) studied this question.

synapsesocial.com/papers/689a0939e6551bb0af8ce6e5https://doi.org/10.1101/2025.07.25.25332196
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