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July 26, 2025Annals of HematologyOpen Access

Infectious complications in CLL/SLL patients receiving Bruton's Tyrosine Kinase inhibitors – systematic review and meta-analysis of randomized controlled trials

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Authors

SBShira BuchritsGTGal TriemanOGOdil Giladi

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Overview

Systematic review finds no overall infection risk increase with BTK inhibitors in CLL/SLL, highlighting pneumonia concerns.

Key Points

  • Bruton's tyrosine kinase inhibitors showed no significant increase in overall infections in CLL/SLL patients.
  • Eighteen randomized controlled trials with 8,324 patients assessed the risk of infections with BTK inhibitors.
  • Pneumonia risk was notably higher with BTK plus anti-CD20 compared to other regimens, with RR 2.18.
  • BTK inhibitors reduced the risk of febrile neutropenia, suggesting a potential advantage in treatment regimens.

Cite This Study

Buchrits et al. (2025) studied this question.

synapsesocial.com/papers/689a0933e6551bb0af8ce573https://doi.org/10.1007/s00277-025-06502-y
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparison of infections in patients with chronic lymphocytic leukemia (CLL) treated with BTKi versus venetoclax obinutuzumab in first line therapy2025
  2. 2Atherosclerotic cardiovascular events associated with BTK inhibitors: a systematic review and meta-analysis of harms2025
  3. 3Real-world comparison of BTKi monotherapy and fixed-duration BTKi–Venetoclax for first line treatment of chronic lymphocytic leukemia patients without TP53 mutations or IGHV rearrangement2025
  4. 4Clinical Outcomes in Patients With CLL Treated With BTKi at a Large US Cancer Center2025
  5. 5Clinical Outcomes in Patients With CLL Treated With BTKi at a Large US Cancer Center2025