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July 26, 2025Molecular Pharmaceutics

Pharmaceutical Nitrosamines: A Comprehensive Review of Health Risks, Detection, Mitigation Strategies Supplemented with CYP450 Interactions as Molecular Simulations for Mechanistic Insight into Carcinogenicity

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Authors

KKKardile Punam KashinathMSMd Samim SardarSRSubhadeep Roy

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Overview

The review analyzes nitrosamines' carcinogenicity, detection methods, and mitigation strategies in pharmaceuticals, highlighting CYP450 interactions.

Key Points

  • Nitrosamines are significant impurities in drugs known for their mutagenic and carcinogenic properties.
  • Comprehensive detection methods such as HPLC, LC-MS, and GC-MS are discussed to monitor nitrosamine contamination.
  • The review emphasizes the importance of risk assessment and mitigation strategies to ensure drug safety.
  • Molecular simulations provide insight into the interactions of nitrosamines with CYP450 isoforms, enhancing understanding of their carcinogenic mechanisms.

Cite This Study

Kashinath et al. (2025) studied this question.

synapsesocial.com/papers/689a0933e6551bb0af8ce542https://doi.org/10.1021/acs.molpharmaceut.4c01173
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