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July 26, 2025Open Access

Impact of Pharmacist-Led Deprescribing Interventions on Medication Related Outcomes Among Older Adults: A Systematic Review and Meta-analysis

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Authors

ZTZelalem Tilahun TesfayeAddis Ababa UniversityBHBoressa Adugna HorsaAmbo UniversityMYMalede Berihun YismawBahir Dar University

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Overview

Systematic review shows pharmacist-led deprescribing improves medication outcomes in older adults, suggesting benefits of intensive interventions.

Key Points

  • MAIN FINDING: Pharmacist-led deprescribing interventions show potential to reduce the medication burden in older adults.
  • KEY EVIDENCE: A meta-analysis of seven studies indicated a mean reduction of -0.55 medications per patient with pharmacist intervention.
  • APPROACH: The review included RCTs and high-quality nonrandomized studies comparing pharmacist-led care to usual practice.
  • SIGNIFICANCE: Findings support integrating pharmacists in care teams to combat polypharmacy and enhance patient safety.

Cite This Study

Tesfaye et al. (2025) studied this question.

synapsesocial.com/papers/689a0933e6551bb0af8ce4e6https://doi.org/10.1101/2025.07.23.25331989
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