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July 25, 2025JNCI Journal of the National Cancer Institute

Immune checkpoint inhibitors as neoadjuvant therapy for resectable non-small cell lung cancer: a systematic review and network meta-analysis

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Authors

RARiona AburakiYFYu FujiwaraSHSaya Haketa

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Overview

Systematic review evaluates neoadjuvant therapy impacts on survival outcomes in patients with NSCLC, suggesting optimal strategies remain unclear.

Key Points

  • Immune checkpoint inhibitors have improved outcomes in patients with resectable non-small cell lung cancer.
  • Comparisons of seven perioperative strategies showed no clear benefit from adding adjuvant ICI therapy to neoadjuvant chemoimmunotherapy.
  • The analysis included 11 randomized controlled trials with 4,532 patients, using a random model network meta-analysis.
  • Further research is essential to establish the best treatment strategies for resectable non-small cell lung cancer.

Cite This Study

Aburaki et al. (2025) studied this question.

synapsesocial.com/papers/689a0933e6551bb0af8ce4c3https://doi.org/10.1093/jnci/djaf190
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Real‐World Study of Resectable <scp>NSCLC</scp> Following Neoadjuvant Immunotherapy: Should Postoperative Adjuvant Immunotherapy be Recommended?2025 · 2 citations
  2. 2Immunotherapy for resectable NSCLC: neoadjuvant/perioperative followed by surgery over surgery followed by adjuvant. Systematic review and meta-analysis with subgroup analyses2025
  3. 3The Utility of Immune Checkpoint Inhibition in the Management of Resectable Non-Small Cell Lung Cancer2025
  4. 4Neoadjuvant therapy of NSCLC: a review of the use and impact of monoclonal antibodies2025
  5. 5Chemoimmunotherapy for Patients with Resectable Non-Small Cell Lung Carcinoma: Real-World Data Analysis from a Surgical Point of View2025