A narrative review on the evolution of islet isolation techniques and improving yields during total pancreatectomy and islet autotransplantation

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Narrative review highlights islet isolation methods' influence on yields and outcomes in chronic pancreatitis patients.

Islet isolation techniques have significantly evolved, improving yields during total pancreatectomy.
Higher islet yields correlate with better insulin independence rates, around 20%-40% at one year.
Factors like pancreatic fibrosis and ischemia times critically affect clinical outcomes.
Standardized protocols are needed to mitigate variability in islet yields and enhance TPIAT success.

Latif et al. (2025) studied this question.

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