July 25, 2025Open Access

Spatiotemporal Coordination of Guidance Cues Directs Multipolar Migration During Retinal Lamination

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MAIN FINDING: Multipolar migration is directed by a combination of repulsive and attractive signaling cues in the developing retina.
KEY EVIDENCE: Disruption of Slit1b/2–Robo2 and Neurturin–Gfrα1 pathways leads to improper positioning of horizontal cells.
APPROACH: The study employs transcriptomics, CRISPR screening, and live imaging to analyze cell migration and signaling.
SIGNIFICANCE: Understanding these signaling pathways is crucial for clarifying retinal development and function in the central nervous system.

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Implication

Research reveals how repulsive and attractive signaling orchestrates horizontal cell migration in retinal development, indicating its role in neuronal positioning.

Cite This Study

Lehtimäki et al. (2025) studied this question.

synapsesocial.com/papers/689a0627e6551bb0af8cdfea https://doi.org/10.1101/2025.07.23.666134

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Implication

Research reveals how repulsive and attractive signaling orchestrates horizontal cell migration in retinal development, indicating its role in neuronal positioning.

Spatiotemporal Coordination of Guidance Cues Directs Multipolar Migration During Retinal Lamination

Key Points

Discussion

Implication

Cite This Study

Spatiotemporal Coordination of Guidance Cues Directs Multipolar Migration During Retinal Lamination

Key Points

Discussion

Implication

Cite This Study

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