July 24, 2025

Developmental window of vulnerability to methylphenidate: Selective reduction of prelimbic PV+ interneurons impairs adult attention

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Chronic exposure to methylphenidate during adolescence leads to reduced PV+ interneuron density in the prelimbic cortex.
Impairments in sustained attention were observed in adult rats following early MPH treatment.
Rats were tested on attention tasks after receiving a clinically relevant dose of MPH for 20 days during adolescence.
These findings emphasize the importance of PV+ interneurons in adult attentional processes and critical developmental periods.

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Chronic MPH exposure reduces PV+ interneurons and impairs attentional performance in rats, highlighting adolescence as a vulnerable period.

Pérez-Colorado et al. (2025) studied this question.

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Chronic MPH exposure reduces PV+ interneurons and impairs attentional performance in rats, highlighting adolescence as a vulnerable period.