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July 24, 2025The OncologistOpen Access

Exploring the Impact of first-line Durvalumab plus chemotherapy on advanced biliary tract cancer: A Systematic Review and Meta-Analysis

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Authors

PRPatrick ReimannESEva-Maria SchneiderADAngela Djanani

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Overview

Systematic review highlights improved overall survival and progression free survival in advanced biliary tract cancer patients treated with durvalumab plus chemotherapy, indicating its effectiveness.

Key Points

  • Main finding shows durvalumab plus gemcitabine/cisplatin improves overall survival in advanced biliary tract cancer.
  • Meta-analysis of 10 trials with 2877 patients demonstrated statistically significant survival benefits.
  • Rigorous trial selection and quality assessment methods ensured credible evidence was included in the analysis.
  • Findings underline durvalumab plus chemotherapy as the current best treatment option, yet stress the need for more real-world data.

Cite This Study

Reimann et al. (2025) studied this question.

synapsesocial.com/papers/689a0621e6551bb0af8cdebdhttps://doi.org/10.1093/oncolo/oyaf224
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1UK Real-World Evidence of Using Durvalumab Plus Cisplatin and Gemcitabine in Advanced Biliary Tract Cancer via an Early Access Scheme2025
  2. 2Comparative efficacy and safety of targeted therapeutics or immunotherapy agents combined with chemotherapy as first-line treatment for advanced biliary tract cancer: a systematic review and network meta-analysis2025
  3. 3Efficacy and safety of durvalumab and gemcitabine-based chemotherapy combined with or without lenvatinib in advanced biliary tract cancer: A retrospective real-world study2025
  4. 4Efficacy and Safety of the Combination of Durvalumab Plus Gemcitabine and Cisplatin in Patients with Advanced Biliary Tract Cancer: A Real-World Retrospective Cohort Study2025
  5. 5Analysis of clinically actionable alterations in baseline tumor versus plasma samples in participants of the TOPAZ-1 study of durvalumab plus gemcitabine and cisplatin in advanced biliary tract cancer2025