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July 23, 2025

The Role of Vitamin D Deficiency in the Progression of Chronic Kidney Disease: Implications for Early Intervention and Management

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Authors

COCollince Odiwuor OgollaMaseno UniversityLKLucy W. KaraniKisii UniversitySMStanslaus MusyokiSoutheastern University

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Implication

Observational cohort study reveals vitamin D deficiency worsens eGFR in CKD patients, suggesting risk management implications.

Key Points

  • Vitamin D deficiency leads to a faster eGFR decline in CKD patients, averaging 3.5 mL/min/1.73m²/year compared to 2.2 for sufficient levels.
  • Analysis of 120 CKD patients indicates a significant correlation between vitamin D levels and eGFR (r = 0.42, p < 0.001).
  • The research highlights a higher rate of end-stage renal disease in deficient patients (28% vs 14%, p = 0.025).
  • Findings suggest vitamin D status could be a modifiable factor in managing CKD progression and risk stratification.

Cite This Study

Ogolla et al. (2025) studied this question.

synapsesocial.com/papers/689a0621e6551bb0af8cdc29https://doi.org/10.21203/rs.3.rs-6692354/v1
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