Cortical Functional Connectivity in Mouse Models of Early Blindness: Enucleation vs. Anophthalmia
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Key Points
Cortical connectivity undergoes significant changes in mouse models of early blindness, particularly through enucleation and anophthalmia.
Enucleated C57Bl/6J mice showed increased infraslow and low delta power, suggesting strain-specific adaptations after visual deprivation.
Network organization shifted towards higher-order visual areas, with primary visual regions showing reduced integration in both models.
Anophthalmic ZRDBA mice displayed connectivity patterns resembling enucleated mice, emphasizing the role of prenatal retinal waves in cortical development.
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Implication
Mouse models of early blindness reveal sensory deprivation alters cortical connectivity, highlighting differences in enucleation and anophthalmia.