July 22, 2025mBioOpen Access

Breaking down biofilms across critical priority fungal pathogens: proteomics and computational innovation for mechanistic insights and new target discovery

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Fungal biofilms pose significant challenges in treating infections caused by pathogens like Candida and Aspergillus.
Advancements in proteomics and computational techniques are essential for accelerating the discovery of new antifungal targets.
The review emphasizes the urgency for novel therapeutic strategies to combat the resistance of fungal biofilms to existing antifungals.
Identification of biological mechanisms of biofilm formation can lead to effective antibiofilm therapies against critical fungal pathogens.

Authors

OBOscar Bruña–RomeroUniversidade Federal de Santa Catarina JGJennifer Geddes‐McAlisterUniversity of Guelph

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Implication

This review uncovers mechanisms of fungal biofilm formation in key pathogens, highlighting proteomics and computational methods for new antifungal discoveries.

Cite This Study

Bruña‐Romero et al. (2025) studied this question.

synapsesocial.com/papers/689a061be6551bb0af8cd8d1 https://doi.org/10.1128/mbio.02303-24

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Implication

This review uncovers mechanisms of fungal biofilm formation in key pathogens, highlighting proteomics and computational methods for new antifungal discoveries.

Breaking down biofilms across critical priority fungal pathogens: proteomics and computational innovation for mechanistic insights and new target discovery

Key Points

Discussion

Implication

Cite This Study

Breaking down biofilms across critical priority fungal pathogens: proteomics and computational innovation for mechanistic insights and new target discovery

Key Points

Discussion

Implication

Cite This Study