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July 22, 2025

Prognostic Significance of Pre-Treatment Serum Markers in Muscle-Invasive Bladder Cancer Under Tri-Modality Therapy

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Authors

YCYu-Chen ChangDTDin‐Li TsanWYWing‐Keen Yap

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Overview

Analysis shows lymphocyte ratios influence tumor control and survival in muscle-invasive bladder cancer, suggesting targeted therapies could optimize outcomes.

Key Points

  • Lower neutrophil-to-lymphocyte ratio values correlate with improved prognosis in muscle-invasive bladder cancer.
  • Higher lymphocyte-to-monocyte ratio values are associated with better locoregional control and survival outcomes.
  • Dose escalation in radiotherapy improves tumor control for patients with lower lymphocyte-to-monocyte ratio values.
  • Finding optimal lymphocyte ratios may guide treatment strategies in improving overall survival for bladder cancer patients.

Cite This Study

Chang et al. (2025) studied this question.

synapsesocial.com/papers/689a061be6551bb0af8cd7f4https://doi.org/10.21203/rs.3.rs-7042522/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Validation of neutrophil-to-lymphocyte ratio for prognosis and treatment selection in muscle-invasive bladder cancer: A single-institutional longitudinal study2025
  2. 2Preoperative Platelet-to-Lymphocyte Ratio as a Predictor of Recurrence and Recurrence-Free Survival in Non-Muscle-Invasive Bladder Cancer Across Different Intravesical Therapies2026
  3. 3The Prognostic Role of Different Blood Cell Count-to-Lymphocyte Ratios in Patients with Lung Cancer at Diagnosis2025 · 3 citations
  4. 4Bladder-sparing trimodal therapy in elderly patients with muscle-invasive bladder cancer: a real-world single-center experience2025
  5. 5The Prognostic Significance of the Serum Inflammatory Marker Ratios, Neutrophil-Lymphocyte, Platelet-Lymphocyte and Monocyte-Lymphocyte in Male Breast Cancer2025