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July 21, 2025Frontiers in ImmunologyOpen Access

Unraveling NK cell heterogeneity through single-cell sequencing: insights from physiological and tumor contexts for clinical applications

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Authors

MSMingshuai ShenYLYutong LiuLSLiang Shao

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Overview

Single-cell sequencing uncovers NK cell heterogeneity in the tumor microenvironment, suggesting new therapeutic approaches for cancer treatment.

Key Points

  • Natural killer cells play a crucial role in tumor immunity, acting as the first line of defense against tumors.
  • Single-cell sequencing technology reveals the gene expression profiles that highlight NK cell heterogeneity within tumor environments.
  • The formation of NK cell diversity is influenced by differentiation, development, and residency in tissues.
  • Exploring drug effects and resistance mechanisms at the single-cell level can optimize personalized NK cell therapies.

Cite This Study

Shen et al. (2025) studied this question.

synapsesocial.com/papers/689a060ee6551bb0af8cd25ahttps://doi.org/10.3389/fimmu.2025.1612352
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