Comparative Efficacy of Treatment Regimens for Chronic Hepatitis D Virus Infection: A Systematic Review and Network Meta‐Analysis

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Discussion

Network meta-analysis reveals combined bulevirtide and PEG-IFN-alpha improves virological outcomes in HDV patients.

Bulevirtide plus PEG-IFN-alpha was more effective than PEG-IFN-alpha alone in achieving virological response.
At the end of treatment, odds ratio for combined therapy versus PEG-IFN-alpha was 8.39, indicating a strong treatment effect.
The study involved 934 patients across 6 randomised studies focusing on the efficacy of different treatment regimens.
Findings suggest that combination therapy may provide better long-term outcomes for chronic HDV infection.

Ouranos et al. (2025) studied this question.

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