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July 16, 2025JAMA Network OpenOpen Access

Pathologic Complete Response and Survival in Rectal Cancer

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Authors

KSKavin SugumarJLJessica J. LieCSChee‐Chee Stucky

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Overview

Meta-analysis reveals no correlation between pathologic complete response and survival in rectal cancer, suggesting reevaluation of pCR's role.

Key Points

  • Main finding indicates no trial-level association between pathologic complete response and survival rates in rectal cancer.
  • Meta-regression analysis of 25 randomized clinical trials showed no significant correlation for overall and disease-free survival.
  • Study analyzed data from 11,882 patients undergoing neoadjuvant therapy before surgery, ensuring robust sample size.
  • Results imply cautious use of pathologic complete response as a surrogate endpoint in rectal cancer prognosis.

Cite This Study

Sugumar et al. (2025) studied this question.

synapsesocial.com/papers/689a02c9e6551bb0af8ccd7fhttps://doi.org/10.1001/jamanetworkopen.2025.21197
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