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July 15, 2025

Supplementary Figure 5 from Validation of Guidelines for Genetic Investigation of Myeloid Neoplasms with Germline Predisposition: Results from a Prospective Cohort Study

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Authors

BTBianca TesiARAnna RobeliusBBBerivan Baskin

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Overview

Cohort study shows overall survival differences in AML and MDS patients based on germline variants, suggesting genetic testing is vital.

Key Points

  • Overall survival was significantly different in AML patients with and without germline variants.
  • The Log-rank test was used to compare survival rates, revealing key insights into genetic predisposition.
  • Patients with P/LP germline variants showed improved survival in both AML and MDS subgroups.
  • These findings highlight the importance of genetic testing for hereditary blood disorders in clinical practice.

Cite This Study

Tesi et al. (2025) studied this question.

synapsesocial.com/papers/689a02bce6551bb0af8cc6bfhttps://doi.org/10.1158/1078-0432.29568271
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Supplementary Figure 4 from Validation of Guidelines for Genetic Investigation of Myeloid Neoplasms with Germline Predisposition: Results from a Prospective Cohort Study2025
  2. 2Supplementary Figure 6 from Validation of Guidelines for Genetic Investigation of Myeloid Neoplasms with Germline Predisposition: Results from a Prospective Cohort Study2025
  3. 3Data from Validation of Guidelines for Genetic Investigation of Myeloid Neoplasms with Germline Predisposition: Results from a Prospective Cohort Study2025
  4. 4Supplementary Figure 1 from Validation of Guidelines for Genetic Investigation of Myeloid Neoplasms with Germline Predisposition: Results from a Prospective Cohort Study2025
  5. 5Supplementary Figure 2 from Validation of Guidelines for Genetic Investigation of Myeloid Neoplasms with Germline Predisposition: Results from a Prospective Cohort Study2025