Intestinal ischemia–reperfusion and blood–brain barrier compromise: pathways to cognitive dysfunction

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Intestinal ischemia–reperfusion disrupts blood–brain barrier integrity, suggesting pathways leading to cognitive dysfunction.

Intestinal ischemia–reperfusion injuries can lead to significant cognitive dysfunction.
The compromised blood–brain barrier allows harmful substances to enter the bloodstream.
Inflammatory mediators from the gut disrupt neuronal function and signaling.
Understanding these pathways could inform new therapeutic strategies for cognitive impairment.

Hammed et al. (2025) studied this question.

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