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July 15, 2025Open Access

A Case of Pediatric Subcutaneous Panniculitis-like T-cell Lymphoma (SPTCL) presenting as HLH

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Authors

MKMeha KrishnareddigariJLJ LiMFMaxwell A. Fung

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Overview

Case report highlights diagnostic challenges of SPTCL in a pediatric patient with HLH, emphasizing genetic evaluation and treatment complexities.

Key Points

  • A pediatric patient presented with HLH, leading to the diagnosis of subcutaneous panniculitis-like T-cell lymphoma (SPTCL) following skin biopsy.
  • Initial evaluations included infectious, autoimmune, and oncologic assessments, which were inconclusive until genetic testing identified a HAVCR2 mutation.
  • Therapeutic regimens such as immunosuppressants and chemotherapy showed variable success, pointing to the complexity in treatment planning for SPTCL.
  • This case emphasizes the need for clinicians to consider SPTCL in cases of pediatric HLH without a clear cause, highlighting the role of skin biopsy in diagnosis.

Cite This Study

Krishnareddigari et al. (2025) studied this question.

synapsesocial.com/papers/689a02b6e6551bb0af8cc500https://doi.org/10.20944/preprints202507.1077.v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Case of Pediatric Subcutaneous Panniculitis-like T-Cell Lymphoma Successfully Treated with Immunosuppressive Therapy2025
  2. 2Subcutaneous Panniculitis-Like T-Cell Lymphoma in Children: Two Case Reports2025
  3. 3Editorial: Refractory and relapsed hemophagocytic lymphohistiocytosis in pediatric population: targeted therapy2025
  4. 4Cutaneous Manifestations in an Infant With Hemophagocytic Lymphohistiocytosis: Case Report2025
  5. 5Immune thrombocytopenia as a rare initial manifestation and complication of Hodgkin lymphoma: a Pediatric case report2025