Overcoming therapy resistance in pancreatic cancer: challenges and emerging strategies

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This review discusses mechanisms of chemo-resistance in pancreatic cancer, suggesting the microbiome may influence treatment outcomes.

Pancreatic cancer is projected to be the second leading cause of cancer-related deaths by 2030 with a 5-year survival rate of approximately 12.5%.
Despite advances, chemotherapy remains the main treatment for pancreatic cancer, though most tumors exhibit significant therapy resistance.
The review highlights established mechanisms that contribute to therapeutic failure and explores emerging theories to address these challenges.
Understanding how the microbiome may affect treatment response presents new opportunities to overcome resistance in pancreatic cancer.

Toit‐Thompson et al. (2025) studied this question.

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