July 14, 2025

Concordance Analysis of Microsatellite Instability via NGS and Mismatch Repair Deficiency via IHC in Endometrial and Colorectal Cancer

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Authors

CNCamilla NeroUniversità Cattolica del Sacro Cuore LSLisa SalvatoreUniversità Cattolica del Sacro Cuore SDSimona DurantiUniversità Cattolica del Sacro Cuore

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Implication

Concordance analysis shows high agreement between NGS for microsatellite instability and IHC for mismatch repair in colorectal cancer, suggesting improved precision for immunotherapy.

Key Points

High agreement between NGS and IHC methods was observed, notably in colorectal cancer cases.
In endometrial cancer, some tumors showed mismatch repair deficiency but lacked detectable microsatellite instability.
Analysis of 520 tumor samples revealed specific genetic mutations and alterations affecting detection methods.
Optimizing microsatellite instability thresholds based on cancer type may enhance patient selection for immunotherapy.

Cite This Study

Nero et al. (2025) studied this question.

synapsesocial.com/papers/689a02b6e6551bb0af8cc1f7 https://doi.org/10.21203/rs.3.rs-6664521/v1

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Implication

Concordance analysis shows high agreement between NGS for microsatellite instability and IHC for mismatch repair in colorectal cancer, suggesting improved precision for immunotherapy.

Concordance Analysis of Microsatellite Instability via NGS and Mismatch Repair Deficiency via IHC in Endometrial and Colorectal Cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

Concordance Analysis of Microsatellite Instability via NGS and Mismatch Repair Deficiency via IHC in Endometrial and Colorectal Cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

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