July 13, 2025Open Access

Homozygous kinase-dead Csf1r mutation in outbred mice reveals essential and redundant functions of tissue resident macrophages

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Discussion

Genetic mutation in Csf1r disrupts macrophage function and impacts hematopoiesis in mice, indicating redundancy in some roles.

Homozygous kinase-dead Csf1r mutation leads to reduced growth and osteopetrosis in adult mice.
Mutant mice exhibit loss of key macrophage populations, affecting hematopoiesis and immune function.
Bone marrow erythropoiesis is maintained despite the lack of CD169+ macrophages, illustrating redundancy.
The findings reveal essential roles for CSF1R-dependent macrophages while indicating some functions may vary across mouse strains.

Jacquelin et al. (2025) studied this question.

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