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July 12, 2025Acta HaematologicaOpen Access

Complexities of MRD Assays in ALL: A Guide for the Practicing Clinician

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Authors

JLJerry LuoLMLori Muffly

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Overview

Review reveals complexities of MRD assays and optimal testing strategies in acute lymphoblastic leukemia, highlighting challenges faced by clinicians.

Key Points

  • Assessment of measurable residual disease (MRD) is crucial for managing acute lymphoblastic leukemia (ALL).
  • Different assays for MRD detection vary in sensitivity, impacting leukemia diagnosis and treatment decisions.
  • Updates on optimal MRD assays for Philadelphia chromosome positive ALL and T-cell ALL are discussed.
  • The review emphasizes the importance of specimen source, including blood and bone marrow, for accurate MRD testing.

Cite This Study

Luo et al. (2025) studied this question.

synapsesocial.com/papers/689a02afe6551bb0af8cbf3ehttps://doi.org/10.1159/000547423
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