Deletion of scarb1 reveals no changes in bone mineral density in osteoblasts or myeloid cells, indicating that pc-oxpls do not affect bone mass via these pathways.
Key Points
SCARB1 deletion in osteoblast progenitors shows no change in bone mass, suggesting its limited role in bone metabolism.
Bone mineral density measurements in Scarb1 knockout mice indicate that PC-OxPLs do not exert adverse effects through osteoblasts.
Micro-CT analysis of cancellous and cortical bone in Scarb1 ΔLysM mice reveals no significant differences from controls.
Findings support the conclusion that PC-OxPLs' negative skeletal effects are not mediated by SCARB1 in the tested cell types.