This review highlights ncRNAs' impact on viral replication and the host immune response, suggesting novel therapeutic targets.
Non-coding RNAs (ncRNAs), once considered transcriptional noise, have emerged as crucial regulators of gene expression in various biological processes, including host-pathogen interactions. In the context of viral infections, ncRNAs play multifaceted roles, influencing both viral replication and the host’s intricate immune response. This review provides an overview of the major classes of ncRNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), highlighting their diverse mechanisms of action in modulating viral life cycles, immune evasion strategies, and the host’s antiviral defenses. We discuss how both host-encoded and virus-encoded ncRNAs contribute to disease progression and explore their potential as diagnostic biomarkers and therapeutic targets. Understanding the complex interplay between ncRNAs and viral infections offers new avenues for developing novel antiviral strategies and immunomodulatory interventions [1, 2].
No takes yet. Share an insight, caveat, or question.
Singh et al. (2025) studied this question.