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August 6, 2025MoleculesOpen Access

Moxifloxacin and BH3 Mimetic-MIM1 Demonstrate a Potential Synergistic Anti-Melanoma Mode of Action by Cytotoxic and Proapoptotic Activity Enhancement in A375 and G361 Melanoma Cells

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Authors

ABArtur BeberokZRZuzanna RzepkaMKMarta Karkoszka

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Overview

Combination therapy using moxifloxacin and MIM1 increases cytotoxicity and proapoptotic effects in melanoma cells, suggesting a new treatment avenue.

Key Points

  • Moxifloxacin and MIM1 together showed significant cytotoxic and proapoptotic effects in melanoma cells.
  • The study revealed for the first time that the MXFL/MIM1 combination intensifies apoptotic activity compared to individual treatments.
  • A375 and G361 melanoma cells were used to assess viability and apoptosis through a variety of experiments.
  • These findings point to targeting the Mcl-1 protein as a promising strategy in melanoma treatment.

Cite This Study

Beberok et al. (2025) studied this question.

synapsesocial.com/papers/689521f09f4f1c896c428943https://doi.org/10.3390/molecules30153272
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