ACC.26 Late-Breaking Clinical Trials | Synapse

ACC.26 Late-Breaking Clinical Trials — American College of Cardiology 2026

11 late-breaking clinical trials presented at ACC 2026, ranked by impact. Each trial includes PICO analysis, expert commentary, key results, and clinical implications.

HI-PEITHO: Ultrasound-facilitated Catheter-directed Thrombolysis Vs Anticoagulation Alone For Acute Intermediate-high-risk Pulmonary Embolism
TBD
— Pulmonary Embolism
CHAMPION-AF: Outcomes In Patients With Atrial Fibrillation Randomized To Receive Left Atrial Appendage Closure Or Oral Anticoagulation
TBD
— Atrial Fibrillation
CHIP-BCIS3: Controlled Trial Of High-Risk Coronary Intervention With Percutaneous Left Ventricular Unloading
TBD
— Interventional
VESALIUS-CV: Evolocumab In Patients Without Significant Atherosclerosis: Results From VESALIUS-CV
TBD
— Lipid / Prevention
STEMI-DTU: Primary Left Ventricular Unloading In Anterior STEMI Without Cardiogenic Shock
TBD
— Acute MI
ORBITA-CTO: A Randomized, Placebo-controlled Trial Of Chronic Total Occlusion PCI In Stable Angina
TBD
— Interventional
Kardinal: Kardinal: A Phase 2 Study Of Tonlamarsen For The Treatment Of Uncontrolled Hypertension
TBD
— Hypertension
GoFreshRx: DASH-patterned Groceries to Reduce Blood Pressure Among Adults With Treated Hypertension
TBD
— Hypertension
Scout-HCM: Mavacamten In Symptomatic Adolescent Patients With Obstructive Hypertrophic Cardiomyopathy
TBD
— Heart Failure
Essence-TIMI 73b: Effect Of Intensive Triglyceride Lowering With Olezarsen On Progression Of Coronary Atherosclerosis
TBD
— Lipid / Prevention
THRIVE Pilot: Effects of a Food-is-Medicine Intervention on Blood Pressure Among Black and Hispanic Adults with Hypertension in Healthy Food Priority Areas
TBD
— Hypertension

Late-Breakers

Trials ranked by impact

11 trials ranked by impact

ACC.26 Late-Breaking Clinical Trials — American College of Cardiology 2026

Late-Breakers

HI-PEITHO

CHAMPION-AF

CHIP-BCIS3

VESALIUS-CV

STEMI-DTU

ORBITA-CTO

Kardinal

GoFreshRx

Scout-HCM

Essence-TIMI 73b

THRIVE Pilot